Hepatitis is mostly caused by infectious pathogenes such as schistosoma, type B or C Hepatitis, or by hepa-toxic substances such as alcohol and fat. These pathogenes can cause serious fibrosis in liver tissues such as cirrhosis and hepatocellular carcinoma (liver cancer).
Prof. Alain DESSEIN (INSERM UMR 906) research team, “immunology and genetics of parasitic diseases”, based in Marseille, France, has acquired unique and internationally renowned skills in the genetics field over the years. Among other projects, they have looked into the common factors of hepatic fibrosis caused by patients infected with schistosoma, one of the major infectious agents of schistosomiasis.The study showed that massive fibrosis caused by schistosoma was mainly pre-determined by the modification of the sequence of several genes in the patient’s genome.
GenePred’s founders decided to use the research on schistosoma to find and patent genetic markers linked to cirrhosis and hepatocellular carcinoma caused by Type C Hepatitis (HCV). The study showed that ACUTE LIVER FIBROSIS CAUSED BY HCV INVOLVED the expression of several genetic polymorphisms. Today, GenePred, in partnership with the UMR 906, identified A PANEL OF MORE THAN 40 GENETIC MARKERS TO PREDICT ACUTE LIVER FIBROSES.